Soliris includes the active component eculizumab and is a type of drug known as a monoclonal antibody. Eculizumab binds to and suppresses an inflammatory protein in the body, preventing the body from attacking and killing sensitive blood cells, kidneys, muscle, and optic neurons, as well as the spinal cord.
Uses
Soliris is used to treat adults and children with paroxysmal nocturnal hemoglobinuria (PNH), a form of blood system disorder. Red blood cells can be damaged in PNH patients, resulting in low blood counts (anemia), weariness, functional problems, discomfort, dark-colored urine, shortness of breath, and blood clots. Eculizumab has the capacity to inhibit the body’s inflammatory response and hence its ability to assault and kill its own sensitive PNH blood cells.
Soliris is also used to treat adults and children with a kind of blood and kidney disorder known as atypical Haemolytic Uremic Syndrome (aHUS). The kidneys and blood cells, including platelets, can become inflamed in people with aHUS, resulting in low blood values (thrombocytopenia and anemia), diminished or lost renal function, blood clots, weariness, and functional issues. Eculizumab has the capacity to inhibit the body’s inflammatory response as well as its ability to assault and kill sensitive blood cells and kidney cells.
Soliris is also used in adult patients who have a kind of muscular condition known as generalized myasthenia gravis (gMG). The immune system attacks and damages the muscles of gMG patients, resulting in significant muscular weakness, reduced movement, shortness of breath, intense tiredness, aspiration risk, and substantial impairment of daily living activities. Soliris can inhibit the body’s inflammatory reaction as well as its capacity to assault and damage the muscle’s ability to improve muscular contraction, hence minimizing illness symptoms and the impact of the disease on everyday activities. Soliris is indicated for those who continue to experience symptoms despite therapy with other MG medications.
Soliris is also used to treat people with neuromyelitis optica spectrum disorder (NMOSD), a condition that predominantly affects the optic nerves and spinal cord. The immune system attacks and damages the optic nerve and spinal cord in NMOSD patients, resulting in blindness in one or both eyes, weakness or paralysis in the arms or legs, painful seizures, loss of sensation, and significant impairment in daily activities. Soliris can inhibit the body’s inflammatory response as well as its capacity to assault and damage its optic neurons and spinal cord, hence lowering illness symptoms and the disease’s influence on everyday activities.
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Reference:
- https://zeepedia.com/medicines/soliris/
- https://www.ema.europa.eu/en/medicines/human/EPAR/soliris
