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Introduction to Janumet (Prescription)

Janumet is a prescription medication used to treat the symptoms of Type 2 Diabetes Mellitus. Janumet can be taken alone or in combination with other drugs.

Janumet belongs to the Antidiabetics, Biguanides/Dipeptidyl Peptidase-IV Inhibitors family of medicines.

Janumet is not known to be safe or effective in adolescents.


Janumet should not be used if you have severe renal disease or diabetic ketoacidosis (see your doctor for insulin therapy).

Janumet may induce lactic acidosis, a potentially fatal disease. If you have even moderate symptoms such as muscular pain or weakness, numbness or coldness in your arms and legs, difficulty breathing, stomach discomfort, nausea with vomiting, slow or irregular heart rate, dizziness, or feeling very weak or exhausted, get emergency medical attention.

Janumet may potentially cause pancreatitis, a dangerous illness. If you have severe stomach aches with or without vomiting, contact your doctor straight once.

What is Janumet Used For?

Janumet is used to enhance blood glucose (sugar) management in individuals with type 2 diabetes. In addition to diet and exercise, it is utilized in the following ways:

  • in patients who are not adequately controlled on metformin (an antidiabetic medicine) alone;
  • in patients who are already taking a combination of sitagliptin and metformin as separate tablets; 
  • in combination with a sulphonylurea, a PPAR-gamma agonist such as thiazolidinedione, or insulin (another type of diabetes medicine) 
  • in patients who are not adequately controlled on this medicine and metformin.

The medication is only available with a prescription.

Side-effects of Janumet 

  • hives,
  • difficulty breathing,
  • swelling in your face or throat,
  • fever,
  • sore throat,
  • burning in your eyes,
  • skin pain,
  • red or purple skin rash that spreads and causes blistering and peeling,
  • severe pain in your upper stomach spreading to your back,
  • nausea,
  • vomiting,
  • loss of appetite,
  • fast heartbeats,
  • unusual muscle pain,
  • feeling cold,
  • dizziness,
  • lightheadedness,
  • tiredness,
  • weakness,
  • stomach pain,
  • irregular heart rate,
  • itching,
  • blisters,
  • breakdown of the outer layer of skin,
  • severe or ongoing pain in your joints,
  • little or no urinating,
  • shortness of breath,
  • swelling in your legs or feet, and
  • rapid weight gain


If you are allergic to metformin or sitagliptin (Januvia), or if you have severe renal problems, you should not use Janumet.

To ensure that Janumet is suitable for you, inform your doctor if you have ever had:

  • cirrhosis of the liver;
  • cardiovascular disease
  • pancreatitis;
  • elevated triglycerides (a form of blood fat);
  • or gallstones
  • alcoholism

Lactic acidosis is a dangerous complication that some metformin users acquire. This is more common if you have liver or renal illness, congestive heart failure, surgery, a heart attack or stroke, a serious infection, are 65 or older, dehydrated, or use a lot of alcohol. Discuss your risk with your doctor.

Take advantage of NSURx for your prescription drugs!

With the NSURx Prescription Benefit Card, you can save money on your Janumet medications at more than 35,000 pharmacies across the United States.

You can save up to 80% on your medication by using an NSURx card. Hundreds of dollars in savings could be yours every time you fill out your prescription.

The more you shop with NSURx, the more NSUR Coins you will receive as a reward.




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